CRTAM
Description
The CRTAM (cytotoxic and regulatory T cell molecule) is a protein-coding gene located on chromosome 11.
CRTAM is a cytotoxic and regulatory T-cell molecule, also known as Class-I MHC-restricted T-cell-associated molecule. It mediates cell-cell adhesion and regulates the activation, differentiation, and tissue retention of various T-cell subsets. Interaction with CADM1 promotes NK cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells, leading to NK cell-mediated rejection of tumors expressing CADM1. CRTAM regulates CD8+ T-cell proliferation in response to TCR activation but is not essential for CD8+ T-cell cytotoxicity. Interaction with SCRIB promotes cellular polarization in a subset of CD4+ T-cells, regulating TCR-mediated proliferation and cytokine production. CRTAM interacts with CADM1 on CD8+ dendritic cells, regulating the retention of activated CD8+ T-cells in lymph nodes. It is essential for the retention of specific T-cell subsets in the intestines, promoting adhesion to gut-associated dendritic cells and potentially influencing the expression of gut-homing molecules and T-cell differentiation. CRTAM exists as a monomer but can form homodimers. It interacts with CADM1 and SCRIB through distinct domains, influencing cellular functions.
CRTAM (Class-I MHC-restricted T-cell-associated molecule) is involved in cell-cell adhesion, playing a crucial role in regulating the activation, differentiation, and tissue retention of various T-cell subsets. CRTAM's interaction with CADM1 enhances natural killer (NK) cell cytotoxicity and interferon-gamma secretion by CD8+ T-cells, contributing to NK cell-mediated tumor rejection. CRTAM also regulates CD8+ T-cell proliferation in response to T-cell receptor activation. Furthermore, CRTAM interacts with SCRIB, promoting cellular polarization in a subset of CD4+ T-cells, influencing TCR-mediated proliferation and cytokine production. CRTAM's interaction with CADM1 on dendritic cells contributes to the retention of activated CD8+ T-cells within lymph nodes. CRTAM is essential for the retention of specific T-cell subsets in the intestines, promoting adhesion to gut-associated dendritic cells and potentially influencing the expression of gut-homing molecules and T-cell differentiation.
CRTAM is also known as CD355.
