CRYGB
Description
The CRYGB (crystallin gamma B) is a protein-coding gene located on chromosome 2.
CRYGB is the human gene encoding gamma-crystallin B, a protein that plays a crucial role in maintaining the transparency and refractive index of the eye lens. Crystallins are classified into two groups: taxon-specific (enzyme) and ubiquitous. Ubiquitous crystallins, like gamma-crystallin B, are the primary proteins found in the vertebrate eye lens. These proteins are highly stable and remain in the lens cells throughout life, contributing to the lens's long-term functionality. Mammalian lens crystallins are categorized into alpha, beta, and gamma families. Gamma-crystallins, including gamma-crystallin B, are a distinct group of symmetrical, monomeric proteins that lack connecting peptides and terminal extensions. They are regulated differently after early development. The human genome contains four active gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) arranged in a tandem cluster.
CRYGB is also known as CRYG2, CTRCT39.
