DAPP1

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Description

The DAPP1 (dual adaptor of phosphotyrosine and 3-phosphoinositides 1) is a protein-coding gene located on chromosome 4.

DAPP1 is a protein encoded by the DAPP1 gene in humans. It functions as a dual adapter for phosphotyrosine and 3-phosphoinositide.

DAPP1 acts as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR) signaling downstream of PI3K.

DAPP1 is also known as BAM32.

Associated Diseases

• endometrial cancer
• isolated agammaglobulinemia
• immune deficiency, familial variable
• hyper-IgM syndrome type 2
• common variable immunodeficiency