DCUN1D5
Description
The DCUN1D5 (defective in cullin neddylation 1 domain containing 5) is a protein-coding gene located on chromosome 11.
DCUN1D5 contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes, which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). DCUN1D5 may play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth.
DCUN1D5 is also known as DCNL5, SCCRO5.
Associated Diseases
- asthma
- plasma fibronectin deficiency
- isolated asymptomatic elevation of creatine phosphokinase
- congenital enteropathy due to enteropeptidase deficiency
- congenital lethal erythroderma
- cancer
