DECR2
Description
The DECR2 (2,4-dienoyl-CoA reductase 2) is a protein-coding gene located on chromosome 16.
Peroxisomal 2,4-dienoyl-CoA reductase is an enzyme that in humans is encoded by the DECR2 gene.
DECR2 is an auxiliary enzyme involved in beta-oxidation, specifically in the degradation of unsaturated fatty enoyl-CoA esters with double bonds at both even and odd positions within peroxisomes. It catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to produce trans-3-enoyl-CoA. DECR2 exhibits activity towards short and medium chain 2,4-dienoyl-CoAs, and also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting it doesn't act as a rate-limiting step in the peroxisomal degradation of docosahexaenoic acid.
DECR2 is also known as PDCR, SDR17C1.
Associated Diseases
- Brugada syndrome
- hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2
- long QT syndrome 15
- Dravet syndrome
