LAMA2 : laminin subunit alpha 2
Description
The LAMA2 (laminin subunit alpha 2) is a protein-coding gene located on chromosome 6.
The LAMA2 gene instructs the production of the alpha-2 subunit of laminin proteins. Laminins are crucial for cell growth, movement, and adhesion, as well as the formation of basement membranes. Specifically, laminin-2 (merosin or laminin-211) and laminin-4 (laminin-221), which both contain the alpha-2 subunit, are particularly important for skeletal muscle stability.
Laminin, a complex protein, plays a crucial role in the organization and development of tissues during embryonic development. It attaches to cells via a high-affinity receptor and interacts with other extracellular matrix components, facilitating the attachment, migration, and organization of cells.
LAMA2 is also known as LAMM, MDC1A.
Associated Diseases
- Laminin subunit alpha 2-related congenital muscular dystrophy
- Muscular dystrophy, limb-girdle, autosomal recessive 23
- Muscular dystrophy, congenital, merosin deficient or partially deficient
- Limb-girdle muscular dystrophy
- LAMA2-related muscular dystrophy
- Cholangiocarcinoma
