LCK
Description
The LCK (LCK proto-oncogene, Src family tyrosine kinase) is a protein-coding gene located on chromosome 1.
LCK may refer to:
LCK is a non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. It is a key player in T-cell antigen receptor (TCR)-linked signal transduction pathways. LCK is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. When the TCR binds to a peptide antigen-bound MHC complex, it facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, recruiting LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Upon stimulation, the TCR recruits the tyrosine kinase ZAP70, which is phosphorylated and activated by LCK. This triggers a cascade of signaling events involving numerous molecules, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules, such as CD2, and plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferation. LCK is expressed throughout thymocyte development and is crucial for regulating maturation events governed by both pre-TCR and mature alpha beta TCR. LCK phosphorylates substrates like RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH, and TYROBP. It interacts with FYB2 (PubMed:27335501).
LCK is also known as IMD22, LSK, YT16, p56lck, pp58lck.
