MAP3K14
Description
The MAP3K14 (mitogen-activated protein kinase kinase kinase 14) is a protein-coding gene located on chromosome 17.
MAP3K14, also known as NF-kappa-B-inducing kinase (NIK), is a MAP kinase kinase kinase enzyme encoded by the MAP3K14 gene in humans. It acts as a serine/threonine protein-kinase, binding to TRAF2 and stimulating NF-κB activity. NIK is a critical kinase in the alternative NF-κB activation pathway and shares sequence similarity with other MAPKK kinases. It participates in an NF-κB-inducing signaling cascade common to receptors of the tumor-necrosis/nerve-growth factor (TNF/NGF) family and the interleukin-1 type-I receptor. MAP3K14 interacts with CHUK, IKK2, and TRAF2.
MAP3K14, also known as NF-κB-inducing kinase (NIK), is a key player in the non-canonical NF-κB signaling pathway. It exclusively activates NF-κB and its transcriptional activity. Through phosphorylation of CHUK/IKKA, it promotes the proteolytic processing of NFKB2/P100, ultimately leading to NF-κB activation via the non-canonical pathway. This pathway regulates genes essential for B-cell survival, lymphoid organogenesis, and immune response. MAP3K14's action might be receptor-selective.
MAP3K14 is also known as FTDCR1B, HS, HSNIK, IMD112, NIK.
