MCM10
Description
The MCM10 (minichromosome maintenance 10 replication initiation factor) is a protein-coding gene located on chromosome 10.
MCM10 is a protein essential for DNA replication in humans. It's a member of the mini-chromosome maintenance (MCM) protein family, which are involved in the initiation of eukaryotic genome replication. MCM10 is a component of the pre-replication complex (pre-RC) and is thought to play a role in forming replication forks and recruiting other DNA replication-related proteins. It interacts with MCM2, MCM6, and the origin recognition protein ORC2. MCM10 is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Research on a similar protein in Xenopus suggests that MCM10 binds to chromatin at the start of DNA replication, after pre-RC assembly but before origin unwinding. Various isoforms of MCM10 have been identified through alternative splicing.
MCM10 is a key replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex to initiate DNA replication. It also plays a crucial role in preventing DNA damage during replication. MCM10 is a key effector of the RBBP6 and ZBTB38-mediated regulation of DNA replication and common fragile sites stability, acting as a direct target of transcriptional repression by ZBTB38. (PubMed:24726359)
MCM10 is also known as CNA43, DNA43, IMD80, PRO2249.
