MOGS
Description
The MOGS (mannosyl-oligosaccharide glucosidase) is a protein-coding gene located on chromosome 2.
Mannosyl-oligosaccharide glucosidase (MOGS) is an enzyme involved in the N-glycosylation pathway. It is a transmembrane protein found in the endoplasmic reticulum of eukaryotic cells. MOGS catalyzes the removal of the terminal glucose residue from a specific oligosaccharide called Glc3Man9GlcNAc2. This reaction is the first step in the trimming process of the N-glycosylation pathway. MOGS belongs to the glycoside hydrolase family 63 and is highly specific to its biological substrate. It does not cleave simple substrates like p-nitrophenyl glucose and does not show activity towards the α(1→3) linkage present in a related oligosaccharide. The minimum substrate for MOGS is a glucotriose molecule linked in the same way as in its native Glc3Man9GlcNAc2 substrate.
MOGS is also known as CDG2B, CWH41, DER7, GCS1.
