NCKAP1L
Description
The NCKAP1L (NCK associated protein 1 like) is a protein-coding gene located on chromosome 12.
NCKAP1L, also known as Hematopoietic protein 1 (HEM-1), is a key regulator of the actin cytoskeleton specifically within hematopoietic cells. It participates in a variety of cellular processes including lymphocyte development, activation, proliferation, and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages. NCKAP1L is a component of the WAVE2 complex, which contributes to F-actin polymerization, and it is also involved in WAVE-independent mechanisms to regulate myosin and actin polymerization. In T-cells, NCKAP1L is essential for proper mTORC2-dependent AKT phosphorylation, cell proliferation, and cytokine secretion.
NCKAP1L plays a crucial role in regulating the actin cytoskeleton, particularly in hematopoietic cells. It is a component of the WAVE2 complex, which signals downstream of RAC to stimulate F-actin polymerization. This complex is essential for the stabilization and/or translation of its proteins in hematopoietic cells. NCKAP1L also participates in WAVE-independent mechanisms to regulate myosin and actin polymerization during neutrophil chemotaxis. Furthermore, it is required for proper mTORC2-dependent AKT phosphorylation, cell proliferation, and cytokine secretion in T-cells. It interacts with various proteins, including ARHGAP4, PIK3C3/VPS34, PPP1R12A/MYPT1, and mTORC2 components like MTOR and RICTOR.
NCKAP1L is also known as HEM1, IMD72.
