NRROS
Description
The NRROS (negative regulator of reactive oxygen species) is a protein-coding gene located on chromosome 3.
NRROS, also known as LRRC33 (Leucine-rich repeat-containing protein 33), is a crucial regulator of transforming growth factor beta-1 (TGFB1) activity, particularly important for microglia function in the nervous system. It facilitates the activation of latent TGFB1 in macrophages and microglia by specifically binding, through disulfide bonds, to the Latency-associated peptide (LAP) – the regulatory chain of TGFB1. This interaction contributes to integrin-dependent activation of TGFB1. NRROS-mediated TGFB1 activation displays a high degree of localization, with limited spread from one microglial cell to neighboring cells. This suggests a targeted and selective activation of TGFB1 by NRROS. NRROS also indirectly influences Toll-like receptor (TLR) signaling, potentially by modulating TGFB1 signaling to inhibit TLR-induced NF-kappa-B activation and cytokine production.
NRROS is also known as ELLP3030, GARPL1, LRRC33, SENEBAC, UNQ3030.
