NSUN3
Description
The NSUN3 (NOP2/Sun RNA methyltransferase 3) is a protein-coding gene located on chromosome 3.
NSUN3 is a mitochondrial tRNA methyltransferase that modifies cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). This methylation occurs at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position. The f(5)c modification allows mt-tRNA(Met) to recognize the AUA codon in addition to the AUG codon, expanding codon recognition during mitochondrial translation.
NSUN3 is also known as COXPD48, MST077, MSTP077.
