PGM3 : phosphoglucomutase 3
Description
The PGM3 (phosphoglucomutase 3) is a protein-coding gene located on chromosome 6.
The PGM3 gene provides instructions for producing the phosphoglucomutase 3 (PGM3) enzyme. This enzyme plays a role in glycosylation, a process where complex chains of sugar molecules (oligosaccharides) are attached to proteins and lipids. Glycosylation modifies proteins and lipids, enabling them to perform a wider range of functions. The PGM3 enzyme converts N-acetylglucosamine-6-phosphate into N-acetylglucosamine-1-phosphate. This conversion is necessary for the synthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), a sugar required to add sugars to developing oligosaccharides during glycosylation.
The PGM3 enzyme catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide essential for multiple glycosylation pathways including protein N- and O-glycosylation. This information is supported by research published in PubMed articles with IDs 24589341, 24698316, and 24931394.
PGM3 is also known as AGM1, IMD23, PAGM, PGM 3.
