HIST1H4H
Hist1h4h: An Overview
Description
Hist1h4h is a protein-coding gene located on chromosome 6 in humans. It encodes the histamine H4 receptor, a type of G protein-coupled receptor (GPCR) that binds to histamine, a neurotransmitter involved in various physiological processes.
Associated Diseases
Mutations in the Hist1h4h gene have been linked to several diseases, including:
- Narcolepsy with cataplexy: A neurological disorder characterized by excessive daytime sleepiness and sudden muscle weakness triggered by emotions.
- Idiopathic hypersomnia with long sleep time: A condition characterized by chronic excessive sleepiness and difficulty waking up.
- Attention deficit hyperactivity disorder (ADHD): A neurodevelopmental disorder characterized by difficulty paying attention, impulsivity, and hyperactivity.
Did you Know ?
Approximately 90% of individuals with narcolepsy with cataplexy have a mutation in the Hist1h4h gene.
