HLA-H
Description
The HLA-H (major histocompatibility complex, class I, H (pseudogene)) is a pseudo gene located on chromosome 6.
HLA-H, also known as HLA-G, is a non-classical major histocompatibility complex (MHC) class I molecule. It is involved in immune tolerance and is expressed primarily in immune-privileged sites, such as the placenta. HLA-G interacts with inhibitory receptors on immune cells, such as killer cell immunoglobulin-like receptors (KIRs) and leukocyte immunoglobulin-like receptors (LILRs), preventing immune rejection of the fetus by the maternal immune system. HLA-G may also play a role in immune regulation in other contexts, such as transplantation and autoimmune diseases.
HLA-H, also known as HLA-G, is a non-classical major histocompatibility complex (MHC) class I molecule. Unlike classical MHC class I molecules, which present peptides to cytotoxic T lymphocytes (CTLs), HLA-G primarily functions in immune tolerance, particularly during pregnancy. It interacts with inhibitory receptors on immune cells, such as killer cell immunoglobulin-like receptors (KIRs) and leukocyte immunoglobulin-like receptors (LILRs), preventing immune rejection of the fetus by the maternal immune system. HLA-G is also involved in suppressing T cell responses, promoting immune cell apoptosis, and regulating immune responses in various contexts, such as transplantation and autoimmune diseases.
HLA-H is also known as HLAHP.
