HMCES
Description
The HMCES (5-hydroxymethylcytosine binding, ES cell specific) is a protein-coding gene located on chromosome 3.
HMCES (5-hydroxymethylcytosine binding, ES cell specific) is a protein involved in DNA repair, specifically targeting abasic sites in single-stranded DNA. It plays a crucial role in maintaining genomic integrity by promoting error-free repair of abasic sites.
HMCES acts as a sensor of abasic sites (missing bases) in single-stranded DNA (ssDNA), a crucial role in maintaining genomic integrity. It promotes error-free repair by forming a covalent cross-link with the abasic site, preventing error-prone repair mechanisms. This cross-link can be reversed or degraded, allowing for accurate repair. HMCES also plays a protective role in B-cell development, limiting deletions during somatic hypermutation of immunoglobulin genes and contributing to class switch recombination.
HMCES is also known as C3orf37, DC12, SRAPD1.
