HMG20A
Description
The HMG20A (high mobility group 20A) is a protein-coding gene located on chromosome 15.
HMG20A is a human gene that encodes for the High mobility group protein 20A.
HMG20A plays a crucial role in neuronal differentiation by acting as a chromatin-associated protein. It functions as an inhibitor of HMG20B, effectively overcoming the repressive effects of the neuronal silencer REST and promoting the activation of neuronal-specific genes. HMG20A is involved in the recruitment of the histone methyltransferase KMT2A/MLL1, leading to increased methylation of histone H3 lysine 4.
HMG20A is also known as HMGX1, HMGXB1.
Associated Diseases
- type 2 diabetes mellitus
- lysosomal storage disease
- alcohol dependence
- systemic lupus erythematosus
- schizophrenia 15
