HOXA4
Description
The HOXA4 (homeobox A4) is a protein-coding gene located on chromosome 7.
HOXA4, encoded by the HOXA4 gene, is a transcription factor that belongs to the homeobox gene family. Homeobox genes are crucial for regulating embryonic development and are found in clusters on different chromosomes. HOXA4 is part of the A cluster on chromosome 7. It binds to DNA and regulates gene expression, influencing morphogenesis and cell differentiation.
HOXA4 is a sequence-specific transcription factor that plays a crucial role in development. It contributes to a regulatory system that determines the spatial organization of cells along the body's anterior-posterior axis. HOXA4 binds to specific DNA sequences within the regulatory regions of its target genes, with varying levels of affinity. The consensus sequences for its binding sites include 5'-TAATGA[CG]-3' (high affinity) and 5'-CTAATTTT-3' (low affinity).
HOXA4 is also known as HOX1, HOX1D.
Associated Diseases
- autosomal recessive spondylocostal dysostosis
- autosomal dominant spondylocostal dysostosis
- thoracolaryngopelvic dysplasia
- thoracomelic dysplasia
- Becker nevus syndrome
- spondylometaphyseal dysplasia, A4 type
- autosomal dominant brachyolmia
- brachyolmia, Maroteaux type
- Klippel-Feil syndrome 3, autosomal dominant
