IBTK
Description
The IBTK (inhibitor of Bruton tyrosine kinase) is a protein-coding gene located on chromosome 6.
IBTK inhibits BTK tyrosine kinase activity, which is crucial for B-cell development. It downregulates BTK kinase activity, interfering with calcium mobilization and NF-kappa-B-driven transcription mediated by BTK.
IBTK is also known as BTBD26, BTKI.
Associated Diseases
- prostate cancer
- plasma fibronectin deficiency
- isolated asymptomatic elevation of creatine phosphokinase
