ICAM2
Description
The ICAM2 (intercellular adhesion molecule 2) is a protein-coding gene located on chromosome 17.
ICAM2, also known as CD102, is a human gene that encodes a protein involved in cell-cell interactions. It belongs to the intercellular adhesion molecule (ICAM) family, which are transmembrane glycoproteins with immunoglobulin-like domains. ICAM2 binds to LFA-1, a leukocyte adhesion protein, and plays a crucial role in spermatogenesis by regulating spermatid adhesion on Sertoli cells. It may also be involved in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion, mediating interactions important for immune responses. ICAM2 interacts with proteins such as EZR and P9, a protein secreted from the bacterium Akkermansia muciniphila.
ICAM2 is also known as CD102.
