IDH2 : isocitrate dehydrogenase (NADP(+)) 2
The IDH2 Gene: A Key Player in Cellular Energy and Health
Description
The IDH2 gene encodes an enzyme called isocitrate dehydrogenase 2 (IDH2). This enzyme, residing within the mitochondria (the energy factories of cells), plays a crucial role in the production of cellular energy.
Specifically, IDH2 converts a compound called isocitrate into another called 2-ketoglutarate, a key molecule in the Krebs cycle, a series of biochemical reactions that generate energy for cell functions.
Associated Diseases
Mutations in the IDH2 gene have been linked to several diseases, including:
- Glioma: A type of brain tumor that affects glial cells, which support neurons.
- Acute myeloid leukemia (AML): A cancer of the blood and bone marrow.
- Cholangiocarcinoma: A cancer of the bile ducts.
Did you Know ?
Approximately 10% of gliomas carry IDH2 mutations, making it one of the most common genetic alterations found in this type of cancer.
