IFI35
Description
The IFI35 (interferon induced protein 35) is a protein-coding gene located on chromosome 17.
IFI35, also known as interferon-induced 35 kDa protein, is a protein encoded by the IFI35 gene in humans.
IFI35 acts as a signaling pathway regulator in the innate immune system. It interacts with NMI to regulate immune responses, preventing proteasome-mediated degradation and dephosphorylation of IFI35. The complex inhibits virus-triggered type I interferon production and negatively regulates NF-kappa-B signaling by inhibiting nuclear translocation and activation of the NF-kappa-B subunit p65/RELA. This inhibition leads to the suppression of endothelial cell proliferation, migration, and re-endothelialization of injured arteries. IFI35 also functions extracellularly as a damage-associated molecular pattern (DAMP) to promote inflammation. Released by macrophages during cell injury and pathogen invasion, it activates NF-kappa-B signaling in adjacent macrophages via Toll-like receptor 4 (TLR4), promoting the release of pro-inflammatory cytokines.
IFI35 is also known as IFP35.
