IFNK
Description
The IFNK (interferon kappa) is a protein-coding gene located on chromosome 9.
Interferon kappa, also known as IFN-kappa, is a protein encoded by the IFNK gene in humans. It belongs to the type I interferon family, a group of glycoproteins crucial for host defense against viral infections. IFNK is expressed in keratinocytes, and its gene is located on chromosome 9, close to the type I interferon cluster. IFN-kappa exhibits antiviral activity that is cell-associated.
IFNK, also known as interferon kappa (IFN-kappa), plays a crucial role in regulating immune cell function. As a cytokine, it provides cellular protection against viral infections in a species-specific manner. This protein activates the interferon-stimulated response element signaling pathway, directly modulating cytokine release from monocytes and dendritic cells. Additionally, IFNK binds to heparin.
IFNK is also known as IFNT1, INFE1.
Associated Diseases
- amyotrophic lateral sclerosis
- acne inversa, familial, 3
- glycoprotein storage disease
- immunodeficiency 51
- proteasome-associated autoinflammatory syndrome 5
- acne inversa, familial, 1
