IL25
Description
The IL25 (interleukin 25) is a protein-coding gene located on chromosome 14.
IL-25 or IL 25 can refer to:
IL-25 is a cytokine produced by various cells, including eosinophils, T-helper type 2 (Th2) cells, and epithelial cells. It plays a role in regulating the adaptive immune response by controlling cytokine production. IL-25 promotes and amplifies T-helper type 2 responses both locally and systemically. It exerts its effects through its receptor, which is composed of IL17RA and IL17RB. This receptor activation triggers the JAK2-STAT5A pathway, leading to the release of type-2 associated cytokines such as IL4, IL9, and IL13. Additionally, IL-25 induces the production of IL8 and IL6 from eosinophils through the activation of MAPK and NF-kappa-B pathways. IL-25 also inhibits the differentiation of T-helper (Th17) cells by promoting the production of IL4, IL5, and IL13.
IL25 is also known as IL17E.
Associated Diseases
- thyroid gland adenocarcinoma
- isolated agammaglobulinemia
- hyper-IgM syndrome type 2
- hyper-IgM syndrome type 3
- common variable immunodeficiency
- immunodeficiency 72 with autoinflammation
- hypertriglyceridemia 2
- severe combined immunodeficiency due to CARD11 deficiency
- immunodeficiency 18
- MHC class II deficiency
- hyper-IgE recurrent infection syndrome 5, autosomal recessive
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
