INCA1
Description
The INCA1 (inhibitor of CDK, cyclin A1 interacting protein 1) is a protein-coding gene located on chromosome 17.
Inhibitor of CDK, cyclin A1 interacting protein 1 is a protein that in humans is encoded by the INCA1 gene.
INCA1 binds to CDK2-bound cyclins, inhibiting the kinase activity of CDK2. This interaction with cyclins is crucial for its function as a CDK inhibitor. INCA1 also suppresses cell growth and proliferation, potentially playing a role in cell cycle regulation. It is essential for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis, and inhibition of cell growth.
INCA1 is also known as HSD45.
Associated Diseases
- keratoconus
- hyper-IgM syndrome type 3
- BENTA disease
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
- hyper-IgM syndrome type 2
- immunodeficiency, common variable, 7
- immunodeficiency 105
- classic Hodgkin lymphoma
- autoimmune lymphoproliferative syndrome type 2B
- lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome
- hyper-IgM syndrome type 5
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
