ING5
Description
The ING5 (inhibitor of growth family member 5) is a protein-coding gene located on chromosome 2.
ING5 is a protein encoded by the ING5 gene in humans. It is similar to ING1, a tumor suppressor protein that interacts with TP53, inhibits cell growth, and induces apoptosis. ING5 contains a PHD-finger, a common motif in proteins involved in chromatin remodeling. It can bind to TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathways. ING5 interacts with EP300 and P53.
ING5 is a component of the HBO1 complex, which acetylates histone H3 at Lys-14 (H3K14ac) and to a lesser extent, histone H4. It is also a component of the MOZ/MORF complex, which has histone H3 acetyltransferase activity. Through chromatin acetylation, ING5 may regulate DNA replication and act as a transcriptional coactivator. It inhibits cell growth, delays S-phase progression, and enhances Fas-induced apoptosis in an INCA1-dependent manner.
ING5 is also known as p28ING5.
Associated Diseases
- urinary bladder cancer
- cancer
- coronary artery disease, autosomal dominant 2
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- familial isolated congenital asplenia
