INHBE
Inhibin B (INHBE)
Description:
Inhibin B (INHBE) is a heterodimeric glycoprotein hormone produced primarily by the granulosa cells of ovarian follicles. It consists of an alpha subunit that is shared with other inhibin isoforms and a unique beta subunit, beta B. INHBE is a member of the transforming growth factor-beta (TGF-Ξ²) superfamily and plays a crucial role in regulating the reproductive system.
Associated Diseases:
Dysregulated levels of INHBE have been associated with various reproductive disorders, including:
- Polycystic Ovary Syndrome (PCOS): Elevated INHBE levels in PCOS can impair follicular development and ovulation.
- Ovarian Hyperstimulation Syndrome (OHSS): High INHBE levels during ovarian stimulation can increase the risk of OHSS.
- Premature Ovarian Failure (POF): Reduced INHBE production can contribute to impaired ovarian function and early menopause.
Did you Know ?
Approximately 70% of women with PCOS have elevated INHBE levels, highlighting its significant role in the pathogenesis of the syndrome.
