INSRR
Description
The INSRR (insulin receptor related receptor) is a protein-coding gene located on chromosome 1.
The INSRR gene encodes for the insulin receptor-related protein in humans.
INSRR is a receptor tyrosine kinase that functions as a pH sensor. Activation by an increase in extracellular pH triggers an intracellular signaling pathway involving IRS1 and AKT1/PKB.
INSRR is also known as IRR.
Associated Diseases
- hereditary sensory and autonomic neuropathy type 4
- familial medullary thyroid carcinoma
- type 2 diabetes mellitus
- glioblastoma
