JMJD8
Description
The JMJD8 (jumonji domain containing 8) is a protein-coding gene located on chromosome 16.
JMJD8 acts as a positive regulator in the TNF-induced NF-kappa-B signaling pathway. It also influences angiogenesis and cellular metabolism by interacting with the PKM protein.
JMJD8 is also known as C16orf20, PP14397.
Associated Diseases
- autosomal recessive spinocerebellar ataxia 16
- cancer
- hemochromatosis type 5
- hyperinsulinism due to INSR deficiency
- hyperinsulinism due to glucokinase deficiency
- exercise-induced hyperinsulinism
- hereditary hyperferritinemia with congenital cataracts
- islet cell adenomatosis
