KCTD12
Description
The KCTD12 (potassium channel tetramerization domain containing 12) is a protein-coding gene located on chromosome 13.
KCTD12 is a protein encoded by the KCTD12 gene in humans. It may be associated with rumination and Bipolar Disorder.
KCTD12 acts as an auxiliary subunit of GABA-B receptors, influencing their pharmacological properties and the speed of their response. It enhances the effectiveness of GABA-B receptor agonists and significantly alters G-protein signaling by accelerating the onset of receptor activation and promoting their desensitization.
KCTD12 is also known as C13orf2, PFET1, PFETIN.
