KDM4D
Description
The KDM4D (lysine demethylase 4D) is a protein-coding gene located on chromosome 11.
KDM4D, encoded by the KDM4D gene in humans, is an enzyme belonging to the alpha-ketoglutarate-dependent hydroxylase superfamily. Its messenger RNA was utilized in the groundbreaking somatic cell nuclear transfer experiment that resulted in the first two cloned primates from post-embryonic donor material in 2017. Additionally, KDM4D played a role in a similar experiment conducted in 2018 aimed at enhancing the cloning efficiency of bovine species.
KDM4D is also known as JMJD2D.
Associated Diseases
- gastrointestinal stromal tumor
- nonpapillary renal cell carcinoma
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 25
- isolated congenital hypogonadotropic hypogonadism
- spermatogenic failures 50
- spermatogenic failure 63
- spermatogenic failure 51
- spermatogenic failure 65
- congenital bilateral absence of vas deferens
- spermatogenic failure 72
- spermatogenic failure, X-linked, 3
- spermatogenic failure 42
- spermatogenic failure 39
