KIAA1841
Kiaa1841: A Promising Biomarker and Therapeutic Target in Neurodegenerative Diseases
Description:
Kiaa1841, also known as Myosin VIIA, is a protein that plays a crucial role in neuronal development and function. It is a motor protein associated with the dynein-dynactin complex, which is involved in cellular transport, vesicle trafficking, and neuronal migration. Kiaa1841 is highly expressed in the brain, particularly in neurons.
Associated Diseases:
Kiaa1841 has been implicated in several neurodegenerative diseases, including:
- Alzheimer's disease (AD): Kiaa1841 is downregulated in AD brains, and its loss is associated with impaired axonal transport and synaptic dysfunction.
- Parkinson's disease: Mutations in the kiaa1841 gene have been linked to familial forms of Parkinson's disease. These mutations disrupt the protein's function, leading to dopaminergic neuron loss and motor symptoms.
- Amyotrophic lateral sclerosis (ALS): Kiaa1841 is decreased in ALS patients, and its deficiency impairs mitochondrial function and axonal survival.
Did you Know ?
- Studies have shown that individuals with low levels of kiaa1841 have a significantly increased risk of developing Alzheimer's disease.
