KLF17
Description
The KLF17 (KLF transcription factor 17) is a protein-coding gene located on chromosome 1.
KLF17 is a protein that in humans is encoded by the KLF17 gene.
KLF17 is a transcription repressor protein that binds to the promoter regions of specific genes, effectively silencing their expression. This protein acts as a negative regulator, hindering epithelial-mesenchymal transition (EMT) and metastasis in breast cancer. Its specific binding to the 5'-CACCC-3' sequence within the promoter of ID1, a crucial metastasis regulator in breast cancer, results in the suppression of ID1 expression. Additionally, KLF17 is likely a germ cell-specific transcription factor, playing significant roles in the differentiation of spermatids and the development of oocytes.
KLF17 is also known as ZLF393, ZNF393, Zfp393.
Associated Diseases
- multiple sclerosis
- Parkinson disease
- Alzheimer disease
- lysosomal storage disease
- cancer
- myoepithelial tumor
