KLK1
Description
The KLK1 (kallikrein 1) is a protein-coding gene located on chromosome 19.
Kallikrein-1 is a protein encoded by the KLK1 gene in humans. It belongs to the peptidase S1 family, a subgroup of serine proteases with diverse physiological functions. Many kallikreins are linked to carcinogenesis and have potential as biomarkers for cancer and other diseases. This gene is part of a cluster of fifteen kallikrein subfamily members located on chromosome 19. Kallikrein-1 is conserved in its ability to release the vasoactive peptide Lys-bradykinin from low molecular weight kininogen.
KLK1 is also known as KLKR, Klk6, hK1.
Associated Diseases
- kallikrein, decreased urinary activity of
- acute kidney failure
- pulmonary hypertension, primary, 1
- dilated cardiomyopathy 1I
- congenitally corrected transposition of the great arteries
- arterial calcification, generalized, of infancy, 2
- familial thoracic aortic aneurysm and aortic dissection
- arterial calcification, generalized, of infancy, 1
