KRT27
Description
The KRT27 (keratin 27) is a protein-coding gene located on chromosome 17.
KRT27 is a keratin gene belonging to the Type I family of intermediate filament proteins.
KRT27 plays a crucial role in the formation of keratin intermediate filaments within the inner root sheath (IRS) of hair follicles. It is essential for the proper assembly of type I and type II keratin protein complexes, which are crucial for the structural integrity of the IRS.
KRT27 is also known as K25IRS3, KRT25C.
Associated Diseases
- ovarian cancer
- low grade glioma
- uncombable hair syndrome
- ringed hair disease
- pili bifurcati
- wooly hair, autosomal recessive 3
- hypotrichosis simplex
- hypotrichosis 4
- epidermolytic palmoplantar keratoderma
- trichodysplasia-xeroderma syndrome
- pili torti
- Marie Unna hereditary hypotrichosis
- autosomal dominant wooly hair
- pili gemini
- monilethrix
- hair defect with photosensitivity and intellectual disability syndrome
