KRT74
Description
The KRT74 (keratin 74) is a protein-coding gene located on chromosome 12.
KRT74 is a gene responsible for producing a type of keratin protein. Mutations in this gene can lead to hair and nail ectodermal dysplasia, a condition affecting hair and nail development.
KRT74 plays a crucial role in hair formation by contributing to the structural integrity of the hair follicle's inner root sheath (IRS). It is believed to be a key component of keratin intermediate filaments within the IRS.
KRT74 is also known as ADWH, ECTD7, HTSS2, HYPT3, K6IRS4, KRT5C, KRT6IRS4.
Associated Diseases
- Woolly hair
- Hypotrichosis simplex of the scalp
- Hypotrichosis 3
- Woolly hair, autosomal dominant
- Ectodermal dysplasia 7, Hair/nail type
