KRT86 : keratin 86
Description
The KRT86 (keratin 86) is a protein-coding gene located on chromosome 12.
Keratin, type II cuticular Hb6 is a protein that in humans is encoded by the KRT86 gene. The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.
KRT86, also known as Keratin, type II cuticular Hb6, plays a crucial role in the formation of hair and nails. It forms heterodimers with type I keratins, ultimately contributing to the structure and integrity of these tissues. Mutations in KRT86 can lead to the development of monilethrix, a rare hair disease.
KRT86 is also known as HB6, Hb1, K86, KRTHB1, KRTHB6, MNX.
