LAMTOR5
Description
The LAMTOR5 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5) is a protein-coding gene located on chromosome 1.
LAMTOR5 is a human gene that encodes a protein involved in amino acid sensing and cell growth regulation. It is a component of the Ragulator complex, which interacts with the mTORC1 complex and small GTPases Rag. LAMTOR5 also interacts with BIRC5, suppressing apoptosis. In addition, LAMTOR5 interacts with the hepatitis B virus (HBV) oncoprotein HBX, suggesting a potential role in viral infection.
LAMTOR5, also known as Ragulator complex protein LAMTOR5, Hepatitis B virus X-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5, is a component of the Ragulator complex. This complex plays a crucial role in amino acid sensing and the activation of mTORC1, a signaling pathway that promotes cell growth in response to various stimuli, including growth factors, energy levels, and amino acids. The Ragulator complex is activated by amino acids through a mechanism involving the lysosomal V-ATPase. It acts as a guanine nucleotide exchange factor (GEF) for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC, and RagD/RRAGD), activating them and mediating their recruitment to the lysosome membrane. The activated Ragulator and Rag GTPases serve as a scaffold, recruiting mTORC1 to lysosomes, where it is activated. Furthermore, LAMTOR5, when complexed to BIRC5, interferes with apoptosome assembly, preventing the recruitment of pro-caspase-9 to oligomerized APAF1 and selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway.
LAMTOR5 is also known as HBXIP, XIP.
Associated Diseases
- lysosomal storage disease
- thyroid gland adenocarcinoma
- endometrial cancer
- ovarian cancer
- urinary bladder cancer
- breast cancer
- cancer
- X-linked retinal dysplasia
- hyperpigmentation with or without hypopigmentation, familial progressive
