LGALS2
Description
The LGALS2 (galectin 2) is a protein-coding gene located on chromosome 22.
Galectin-2 is a protein encoded by the LGALS2 gene in humans. It is a soluble beta-galactoside binding lectin that forms a homodimer and can bind to Lymphotoxin alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, leading to an increased risk of myocardial infarction.
This protein binds beta-galactoside. Its physiological function is not yet known.
LGALS2 is also known as HL14.
Associated Diseases
- isolated agammaglobulinemia
- common variable immunodeficiency
- cancer
- immunodeficiency 72 with autoinflammation
- severe combined immunodeficiency due to CARD11 deficiency
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
- severe combined immunodeficiency due to IKK2 deficiency
- combined immunodeficiency due to ZAP70 deficiency
- immunodeficiency 18
- autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- severe combined immunodeficiency due to CTPS1 deficiency
- neutrophil immunodeficiency syndrome
- immunodeficiency 105
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
