LGR6
Description
The LGR6 (leucine rich repeat containing G protein-coupled receptor 6) is a protein-coding gene located on chromosome 1.
LGR6, also known as Leucine-rich repeat-containing G-protein coupled receptor 6, is a protein encoded by the LGR6 gene in humans. It plays a crucial role in the Wnt signaling pathway, alongside other G-protein coupled receptors like LGR4 and LGR5. LGR6 also serves as a marker for epithelial stem cells in squamous cell carcinoma in mice. As a member of the leucine-rich repeat-containing G-protein coupled 7-transmembrane protein superfamily, LGR6 is a glycoprotein hormone receptor with a large N-terminal extracellular domain containing leucine-rich repeats. These repeats are essential for forming a horseshoe-shaped interaction motif that binds ligands. Alternative splicing of the LGR6 gene generates multiple transcript variants.
LGR6 is a receptor for R-spondins, a group of proteins that enhance the Wnt signaling pathway. When R-spondins bind to LGR6, they form a complex with phosphorylated LRP6 and frizzled receptors, which are activated by Wnt proteins. This complex triggers the canonical Wnt signaling pathway, leading to increased expression of target genes. Unlike typical G-protein coupled receptors, LGR6 does not activate G-proteins to transmit signals. It may also act as a tumor suppressor.
LGR6 is also known as GPCR, VTS20631.
