LITAF
Description
The LITAF (lipopolysaccharide induced TNF factor) is a protein-coding gene located on chromosome 16.
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) is a protein encoded by the LITAF gene in humans. It is also known as Small integral membrane protein of lysosome/late endosome, p53-induced gene 7 protein.
LITAF plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). It helps target endocytosed EGFR and ERGG3 for lysosomal degradation, thereby down-regulating downstream signaling cascades (PubMed:23166352). LITAF also recruits ESCRT complex components TSG101, HGS, and STAM to cytoplasmic membranes (PubMed:23166352). It likely plays a role in regulating protein degradation through its interaction with NEDD4 (PubMed:15776429). LITAF may also contribute to regulating gene expression in the nucleus (PubMed:10200294, PubMed:15793005). It binds DNA in vitro and may synergize with STAT6 in the nucleus to regulate the expression of various cytokines (PubMed:15793005). LITAF can regulate the expression of numerous cytokines, including TNF, CCL2, CCL5, CXCL1, IL1A, and IL10 (PubMed:10200294, PubMed:15793005).
LITAF is also known as PIG7, SIMPLE, TP53I7.
