LOC100132831
Loc100132831: An Exciting Target for Cancer Therapy
Description:
Loc100132831, also known as the fragile histidine triad (FHIT) gene, is a tumor suppressor gene located on chromosome 3p14.2. It plays a crucial role in maintaining genomic stability by repairing DNA damage and regulating cell growth.
Associated Diseases:
Inactivation of the FHIT gene has been linked to several types of cancer, including:
- Lung cancer
- Esophageal cancer
- Head and neck cancer
- Breast cancer
- Colorectal cancer
FHIT mutations are particularly common in squamous cell carcinomas, accounting for up to 65% of cases.
Did you Know ?
Approximately 10% of all human cancers harbor FHIT mutations. This high prevalence underscores the importance of FHIT in cancer development.
