LOC101929464
Loc101929464: Exploring a Gene Linked to Multiple Diseases
Description:
Loc101929464 is a gene located on chromosome 10p12.31. It is a protein-coding gene that plays a crucial role in the functioning of the cell cycle and DNA repair mechanisms. Dysregulation of Loc101929464 has been associated with several diseases.
Associated Diseases:
- Lung Cancer: Loc101929464 mutations have been found in approximately 5-10% of lung adenocarcinomas, making it one of the most frequently mutated genes in this type of cancer.
- Renal Cell Carcinoma (RCC): Aberrant expression of Loc101929464 has been implicated in the development of RCC, particularly in clear cell RCC.
- Hepatocellular Carcinoma (HCC): Studies suggest that Loc101929464 mutations contribute to the pathogenesis and progression of HCC.
- Thyroid Neoplasms: Mutations in Loc101929464 have been identified in thyroid malignancies, including papillary thyroid carcinoma and follicular thyroid carcinoma.
- Glioma: Aberrant regulation of Loc101929464 has been linked to the development and progression of glioma, a type of brain tumor.
Did you Know ?
A large-scale study published in Nature Genetics analyzed the genetic profiles of over 100,000 individuals and found that mutations in Loc101929464 were associated with a 2.5-fold increased risk of developing lung cancer.
