LRRC23
Description
The LRRC23 (leucine rich repeat containing 23) is a protein-coding gene located on chromosome 12.
LRRC23, short for Leucine-rich repeat-containing protein 23, is a protein found in humans. It's encoded by the LRRC23 gene. While the exact function of LRRC23 is not fully understood, it belongs to the leucine-rich repeat family of proteins, known for their role in protein-protein interactions. Research suggests that LRRC23 interacts with the CD28 protein, potentially influencing immune responses and the development of regulatory T cells, which help control autoimmune diseases. LRRC23 has a structure that includes two types of repeating sequences: leucine-rich repeats (9 times) and another repeating sequence (2 times). The human genome generates three variations of LRRC23, with the largest version containing 8 exons.
LRRC23 is also known as LRPB7, SPGF92.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- colorectal cancer
- spermatogenic failure 49
- spermatogenic failure 19
- spermatogenic failure 45
- spermatogenic failure 43
- spermatogenic failure 27
- spermatogenic failure 18
- spermatogenic failure 46
- spermatogenic failure 72
- spermatogenic failure 11
- spermatogenic failure 10
- spermatogenic failure 65
- spermatogenic failure 42
- spermatogenic failure 47
- spermatogenic failure, X-linked, 3
- spermatogenic failure 40
- spermatogenic failure 7
