LTB
Description
The LTB (lymphotoxin beta) is a protein-coding gene located on chromosome 6.
LTB, or Lymphotoxin beta, is a human protein involved in immune response regulation. It is a cytokine that binds to the LTBR/TNFRSF3 receptor and acts as a membrane anchor for a heterotrimeric complex. While LTB has various meanings, this refers specifically to the human gene and its protein product.
Lymphotoxin-beta (LT-beta) is a cytokine that binds to the LTBR/TNFRSF3 receptor, potentially influencing immune response regulation. It serves as a membrane anchor for the heterotrimeric complex, attaching it to the cell surface. Isoform 2 is likely non-functional.
LTB is also known as TNFC, TNFSF3, TNLG1C, p33.
Associated Diseases
- hyper-IgM syndrome type 2
- hyper-IgM syndrome type 3
- severe combined immunodeficiency due to CD70 deficiency
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
- hyper-IgM syndrome type 5
- immunodeficiency 75
- immunodeficiency 72 with autoinflammation
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
- immunodeficiency 78 with autoimmunity and developmental delay
- isolated agammaglobulinemia
- common variable immunodeficiency
- autoimmune lymphoproliferative syndrome type 2B
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
- severe combined immunodeficiency due to LAT deficiency
- hyper-IgM syndrome type 4
