LTB4R
LTB4 Receptor (LTB4R): A Key Player in Immune Regulation and Disease Pathogenesis
Description:
The leukotriene B4 receptor (LTB4R) is a G protein-coupled receptor that binds to leukotriene B4 (LTB4), a potent lipid mediator produced by activated immune cells. LTB4R is expressed on neutrophils, eosinophils, macrophages, and dendritic cells, and its activation triggers a cascade of intracellular signaling events that regulate immune cell function.
Associated Diseases:
LTB4 and LTB4R have been implicated in a wide range of inflammatory and autoimmune disorders, including:
- Asthma
- Chronic obstructive pulmonary disease (COPD)
- Rheumatoid arthritis
- Inflammatory bowel disease
- Multiple sclerosis
- Atopic dermatitis
Did you Know ?
In patients with severe asthma, LTB4 levels in the airways are significantly increased, suggesting that LTB4 and LTB4R play a significant role in the pathogenesis of this chronic respiratory condition.
