MAD2L1
Description
The MAD2L1 (mitotic arrest deficient 2 like 1) is a protein-coding gene located on chromosome 4.
MAD2L1 is a human gene that encodes the mitotic spindle assembly checkpoint protein MAD2A. It plays a crucial role in ensuring proper chromosome segregation during cell division by preventing the onset of anaphase until all chromosomes are correctly aligned at the metaphase plate.
MAD2L1 is a key component of the spindle-assembly checkpoint, preventing the start of anaphase until all chromosomes are properly aligned at the metaphase plate. It exists in two conformations: closed (C-MAD2) and open (O-MAD2). During prometaphase, C-MAD2 forms a complex with MAD1L1 at unattached kinetochores, recruiting O-MAD2 and promoting its conversion to C-MAD2. This checkpoint mechanism monitors kinetochore-spindle attachment and inhibits the anaphase promoting complex by sequestering CDC20, ensuring proper chromosome alignment before proceeding to anaphase.
MAD2L1 is also known as HSMAD2, MAD2.
