MAGEA2B
Description
The MAGEA2B (MAGE family member A2B) is a protein-coding gene located on chromosome X.
MAGEA2B reduces the transactivation function of p53/TP53 by recruiting HDAC3 to its transcription sites. It also represses p73/TP73 activity. MAGEA2B is thought to enhance the ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro studies have shown that MAGEA2B enhances the ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28, potentially in the presence of the Ubl-conjugating enzyme UBE2H. MAGEA2B is proposed to act by recruiting and/or stabilizing the Ubl-conjugating enzyme (E2) at the E3:substrate complex. MAGEA2B may play a role in embryonal development, tumor transformation, or aspects of tumor progression. In vitro, MAGEA2B promotes cell viability in melanoma cell lines. It is an antigen recognized by autologous cytolytic T-lymphocytes on melanoma cells. MAGEA2B negatively regulates the acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.
MAGEA2B is also known as CT1.2, MAGE2.
