MALAT1
Description
The MALAT1 (metastasis associated lung adenocarcinoma transcript 1) is a ncRNA gene located on chromosome 11.
MALAT1 (metastasis associated lung adenocarcinoma transcript 1), also known as NEAT2 (noncoding nuclear-enriched abundant transcript 2), is a large, infrequently spliced non-coding RNA, which is highly conserved amongst mammals and highly expressed in the nucleus. It regulates the expression of metastasis-associated genes. It also positively regulates cell motility via the transcriptional and/or post-transcriptional regulation of motility-related genes. MALAT1 may play a role in temperature-dependent sex determination in the Red-eared slider turtle (Trachemys scripta).
== Expression in alcoholic brains == Transcripts of MALAT1 are significantly increased in the cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. This alcohol-induced upregulation of MALAT1 may be responsible for differential expression of a number of proteins which contribute to ethanol tolerance and dependency in humans.
== Prognostic potential in cancer == Elevated MALAT1 expression is correlated with poor overall survival in various types of cancer, suggesting that this gene is a prognostic factor for different types of cancer.
MALAT1 is also known as HCN, LINC00047, NCRNA00047, NEAT2, PRO2853.
Associated Diseases
- breast cancer
- cancer
- Miyoshi myopathy
- pachyonychia congenita
- microphthalmia with limb anomalies
- retinoblastoma
- bronchopulmonary dysplasia
- urinary bladder carcinoma
